Fibulin-5 interacts with fibrillin-1 molecules and microfibrils
Open Access
- 10 May 2005
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 388 (1) , 1-5
- https://doi.org/10.1042/bj20050368
Abstract
Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin. Fibulin-5 interacted in a dose-dependent manner with a fibrillin-1 N-terminal sequence and with tropoelastin, but not with MAGP-1 (microfibril-associated glycoprotein-1) or decorin. Fibulin-5 did not inhibit interactions between fibrillin-1 N- and C-terminal fragments, or fibrillin-1 interactions with tropoelastin. Fibulin-5 may provide a link between tropoelastin and microfibrils in the pericellular space during elastic fibre assembly.Keywords
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