Comparison of Effects of Various Phosphate Compounds and Aluminum Silicate on Isolated Frog Heart

Abstract
ATP, ADP, sodium tripolyphosphate and aluminum silicate restored the amplitude of contraction in hearts depressed by reduced Ca, excess K, or acetylmethylcholine chloride. In general, ATP was the most effective compound. ATP alone was effective in hearts depressed by N2 plus IAA. ATP and ADP restored the excitability in hearts depressed by excess K. None of the 4 compounds studied had any effect on the freshly excised heart perfused with oxygenated Ringer.