Tumor Necrosis Factor–α and Interleukin‐1β Play a Critical Role in the Resistance against Lethal Herpes Simplex Virus Encephalitis
- 15 September 2007
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 196 (6) , 853-860
- https://doi.org/10.1086/520094
Abstract
Background. The innate immune response after herpes simplex type 1 (HSV-1) encephalitis could be protective or, paradoxically, implicated in neuronal damage. We investigated the role of the innate immune response in such infection using a C57BL/6 mouse knockout (KO) model for tumor necrosis factor (TNF)-α and/or interleukin (IL)-1β.Keywords
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