Molecularly Imprinted Polymers Selective for β-Estradiol
- 1 October 1998
- journal article
- research article
- Published by Taylor & Francis in Supramolecular Chemistry
- Vol. 9 (4) , 317-323
- https://doi.org/10.1080/10610279808035001
Abstract
Polymers able to recognize the female steroid hormone, β-estradiol, have been synthesized using molecular imprinting based on non-covalent interactions. A chromatographic study of the polymers demonstrated a strong dependence of the selectivity and strength of their interaction with analytes on the solvents used both as porogen and chromatographic mobile phase. Hydrogen bonding between the OH-group at C-17 of β-estradiol and methacrylic acid (the functional monomer of the polymer) plays a major role in the process of molecular recognition but hydrophobic and dipole-dipole interactions also contribute.Keywords
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