Continuous Enrichment of Albumin in Relation to Globulins in Plasma

Publisher Website
Google Scholar
Abstract
The problem of continuous separation of albumin from globulins in patient''s plasma and reinfusion of the useful components of the plasma to the patient as the substitution fluid during a plasma exchange (PE) treatment was studied. A cascade filtration system was developed to generate continuously 2 plasma fractions, one rich in globulins and the other rich in albumins, using 2 filters (H1P100 filter with a MW cutoff of 100,000 and Diafilter 20 with a MW cutoff of 30,000). The system is able to increase the albumin/globulin ratio of plasma from 0.42 to 1.98; the albumin concentration in the secondary plasma fraction is .apprx. 7 times higher than that in the primary plasma fraction. This system is expected to be clinically useful in eliminating the side effects inherent in the usage of any other substitution fluid during a PE treatment. [PE has been used to treat immunologically-mediated diseases.].