Abstract
The precipitating and perpetuating factors in the various shock syndromes are considered in terms of alteration in responsiveness of the peripheral vascular bed to vasopressor agents. The value of vasopressor agents are then considered in relation to the effects on the peripheral vascular bed and on cardiac output. Differences of action of vasopressor drugs in the normal and during the shock state are reviewed and the specific clinical situations in which vasopressor therapy may be of value are discussed.

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