Performance of the Heart: Changes in Left Ventricular End-Diastolic Pressure and Stroke Work During Infusion and Following Exercise

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Abstract
Results show gradation in the degree of directional correlation between left ventricular end-diastolic pressure, stroke volume and stroke work. In the open-chest dog, data are in accord with those of Wiggers and Katz, showing almost perfect correlation between end-diastolic pressure and stroke volume and stroke work. In the closed-chest dog with rapid infusion, associated with an increased venous return and an increased total blood volume, agreement is excellent; with moderate infusions there are exceptions. As one more closely approximates the normal state the deviations are larger and more numerous. In the essentially normal dog in which heart rate, size of the great veins and atrial compartments, peripheral resistance, cardiac output, end-diastolic pressure, and cardiac size, all can vary greatly and quickly as the result of treadmill exercise and excitement, there is no directional correlation between left ventricular end-diastolic pressure, stroke volume and stroke work or any of the other parameters measured or calculated.