Role of Microtubuli in the Lysosomal Degradation of Endogenous and Exogenous Protein in Isolated Rat Hepatocytes
- 1 January 1981
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 362 (1) , 549-556
- https://doi.org/10.1515/bchm2.1981.362.1.549
Abstract
Colchicine and vinblastine, 2 inhibitors of microtubular function, inhibited endogenous protein degradation as well as protein secretion and the degradation of an exogenous, internalized protein (asialo fetuin) in isolated rat hepatocytes. The inhibitors appeared to selectively affect the lysosomal pathway of degradation since their effects were not additive to that of ammonia, a lysosomotropic degradation inhibitor.This publication has 32 references indexed in Scilit:
- Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytesBiochimica et Biophysica Acta (BBA) - General Subjects, 1980
- The effects of colchicine and cytochalasin B on uptake and degradation of asialo-glycoproteins in isolated rat hepatocytesExperimental Cell Research, 1979
- Uptake and degradation of 125I-labelled asialo-fetuin by isolated rat hepatocytesBiochimica et Biophysica Acta (BBA) - General Subjects, 1977
- EndocytosisAnnual Review of Biochemistry, 1977
- Plasma protein synthesis by isolated rat hepatocytes.The Journal of cell biology, 1977
- Ammonia inhibition of protein degradation in isolated rat hepatocytesExperimental Cell Research, 1976
- Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2Annual Review of Biochemistry, 1976
- Colchicine inhibition of plasma protein release from rat hepatocytes.The Journal of cell biology, 1975
- Studies on cellular autophagocytosisExperimental Cell Research, 1974
- Preparation of rat liver cellsExperimental Cell Research, 1973