Fascicular nerve allograft evaluation

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Abstract
In a comparative experiment, transplantation of orthotopic nerve fascicle was performed on 100 sciatic nerves between inbred, antigenically identified rats. Cellular response, macrophage reaction, connective-tissue reaction, myelination and distal/proximal axonal ratios were studied, but no difference could be established between allografted and autografted fascicles after 2 mo. There was no evidence of any graded rejection phenomenon dependent on differences of tissue typing. Theories for the decreased antigenic reaction of nerve fascicles were proposed.