Pregnancy-specific β1-glycoprotein (SP1) in serum from women with pregnancies complicated by intrauterine growth retardation

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Abstract
Serum concentrations of pregnancy-specific .beta.1-glycoprotein (SP1) were measured by nephelometry in 37 women with single pregnancies complicated by intrauterine growth retardation (IUGR). Blood samples (67) were examined for their contents of SP1 in pregnancy wk 29-40. SP1 values were compared with those obtained in a cross-sectional study of 323 women and a serial study of 21 women (210 samples) with uncomplicated single pregnancies. A serum SP1 value below 80 mg/l in a single blood sample drawn in pregnancy wk 32-34 had a predictive value of 50% for IUGR and a value above or at 80 mg/l had a value of 93% for predicting a normal infant birth weight. Serial samples from individual women with uncomplicated single pregnancies showed an average increase in the SP1 concentration of 49% from pregnancy wk 30-36. In serial samples from 6 women with IUGR infants, there was no such increase, or a decrease occurred. SP1 measurements in maternal serum are valuable for the detection and monitoring of pregnancies complicated by IUGR.