The cerebrospinal fluid choline levels in patients with Huntington's chorea

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Abstract
Lumbar cerebrospinal fluid (CSF) choline (CH) levels were measured in patients with Huntington's chorea (n = 14). This group was found not to differ significantly from normal controls (n = 13). The values for lumbar CSF Ch levels in the normal subjects were comparable with previously reported values. Of the choreic patients, seven were put on haloperidol treatment (4–6 mg daily). The CSF choline level remained unchanged with this treatment after 20 days. CSF cholinesterase activity was measured in the control and choreic group. The results were not significantly different. Im lumbalen Liquor cerebrospinalis wurde der Cholingehalt bei 14 Fällen von Huntington bestimmt. Im Vergleich zu 13 Gesunden wurden keine signifikanten Unterschiede gefunden. 7 Chorea-Patienten wurden mit Haloperidol 4–6 mg täglich behandelt. Der Cholingehalt des Liquors blieb auch nach Halloperidol über 20 Tage unverändert. Auch die Cholinesteraseaktivität im Liquor war bei Chorea-Kranken und Kontrollen unverändert