DNA demethylation in erythroleukaemia cells
- 20 August 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 269 (1) , 29-31
- https://doi.org/10.1016/0014-5793(90)81111-z
Abstract
Despite a fall in the proportion of CGs methylated, evidence has not been obtained for significant demethylation of prelabelled DNA when mouse erythroleukaemia cells are induced to differentiate. There is, however, a delay in the methylation of the DNA that is synthesised in the early period of induction, leading to its undermethylation by 30–50% and this may be a contributory cause of the observed fall in CG methylation.Keywords
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