The Consequences of Iodine Deficiency

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Abstract
Iodine deficiency is responsible for endemic goiter, endemic cretinism, and several other important related disorders, especially in the developing regions of the world. Where iodized salt is not a feasible or immediately implementable prophylactic resource, iodinated oil by oral or parenteral administration serves admirably. A review of the evidence provides no rationale for withholding iodinated oil during pregnancy. Endemic cretinism may be expressed primarily in a myxedematous form or a form in which neurological manifestations predominate. Mixed forms are often seen. The factor of accompanying selenium deficiency may account for the differences. The rationale for this is explored in terms of the selenoenzymes, glutathionine peroxidase, and type 1 thyroxine deiodinase. (C) Lippincott-Raven Publishers.

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