DIFFERENTIATION OF FIBROBLAST-LIKE CELLS INTO MACROPHAGES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (7) , 2891-2899
Abstract
Differentiated cells with the morphological, enzymatic, antigenic and functional characteristics of macrophages formed when a variety of nontransformed and transformed fibroblast-like mouse embryo cell lines were grown in a medium supplemented only with human plasma. Differentiated cells contained numerous lysosomes and phagosomes, nonspecific esterase and acid phosphatase activities, and cell surface Ia antigens and were capable of phagocytosis of Fe particles. Differentiated cells were also growth arrested in the G1 phase of the cell cycle but growth arrest and differentiation were reversible processes. Cells with the morphology of fibroblasts have the capacity to undergo nonterminal differentiation into macrophages. [These results are used to discuss the histogenesis of fibrous histiocytoma.].

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