Genetics of lycopene cyclization and substrate transfer in β-carotene biosynthesis inPhycomyces

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Abstract
SUMMARY: The mutations which block lycopene cyclization and those which stop substrate transfer along the carotene pathway are very closely linked inPhycomyces. Simultaneous blocking of both processes commonly results from single exposures to mutagens; and both blockings may be simultaneously removed after a second exposure. The frequencies of different kinds of mutants after treatments with the mutagensN-methyl-N′-nitro-N-nitrosoguanidine and ICR-170, their reversion patterns, and recombination analyses indicate that lycopene cyclization and substrate transfer are governed by separate segments of a single bifunctional gene.
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