Fibrous Dysplasia of the Skull and its Differential Diagnosis

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Abstract
The skull is a frequent site of the pathologic process now known as fibrous dysplasia and the skull changes are often the only manifestation of the disease. The roentgenographic appearance in the cranial bones ranges from small, simple translucent areas to massive, sclerotic overgrowth. In many instances the disease is easily recognized but, due to the wide range of its roentgen manifestations, it can simulate and be imitated by numerous other conditions, particularly the hyperostoses associated with a meningioma. In order to increase our knowledge of the natural history and the varied roentgenographic appearance of this disease, we have reviewed the literature and analyzed films and clinical records of 46 patients with fibrous dysplasia involving the skull and facial bones seen at the Columbia-Presbyterian Medical Center. Clinical Features The 46 patients upon whom this study is based included 24 males and 22 females, ranging from two to sixty-eight years of age. Material for microscopic examination was ...

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