A THERAPEUTIC AND DISCONTINUATION STUDY OF CLOBAZAM AND DIAZEPAM IN ANXIETY NEUROSIS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 43  (9) , 372-374
Abstract
The efficacy and safety of clobazam and diazepam were compared in 40 patients with generalized anxiety disorder in a 28 day non-placebo-controlled trial followed by a 3-day single-blind placebo washout. The 2 drugs were equally anxiolytic, and the anxiety symptoms of most patients were brought under control within 1 wk. Both drugs were nontoxic. Diazepam had slightly greater sedative properties than clobazam, which was the patients'' preferred drug after 28 days of treatment. During placebo washout, anxiety returned to pretreatment levels. Abrupt withdrawal did not result in rebound phenomena.

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