RESPIRATORY CHANGES IN PULMONARY VASCULAR CAPACITY

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Abstract
Under simplified conditions, using perfused terrapin hearts and mammalian heart-lung preps. enclosed in an artificial thorax, the effects of inspiration upon the heart were studied. Aspiration of blood into the right heart occurred with a resulting increase in output. This increased volume output of the right ventricle was not as great as the increased capacity of the pulmonary vessels. A decreased filling and output of the left ventricle resulted from the increased pulmonary vascular capacity. The changes in vascular capacity of excised dog''s lungs accompanying inflation by a negative pressure of 4 ins. of water and deflation by a return to atmospheric pressure were measured. The magnitude of the increase in pulmonary vascular capacity in inspiration was adequate to accommodate the extra blood pumped by the right ventricle in inspiration.

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