Active Efflux of Norfloxacin by Bacteroides fragilis
- 1 August 1998
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 42 (8) , 2119-2121
- https://doi.org/10.1128/aac.42.8.2119
Abstract
Norfloxacin was actively pumped out by Bacteroides fragilis , which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.Keywords
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