Localization Properties of Radioiodinated Fragments of Antirat Kidney Antibody
Open Access
- 1 July 1961
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 87 (1) , 106-109
- https://doi.org/10.4049/jimmunol.87.1.106
Abstract
Summary: Rabbit antibodies against rat kidney were digested by papain and the fragments were trace labeled with radioiodine and studied with respect to their in vivo localizing and in vitro adsorption properties. γ-Globulin fragments from normal rabbit and rabbit anti-beef γ-globulin sera were used as controls. The kidney-localizing activity was found in fragments I and II of antirat kidney γ-globulin. The fixation of fragments in the kidney, however, was of short duration compared with that of the intact antibody. The adsorption of fragments with kidney sediment also indicated the presence of antibody activity in fragments I and II.Keywords
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