Enantioselective synthesis of α-hydroxyphosphonates through asymmetric Pudovik reactions with chiral lanthanoid and titanium alkoxides
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 1527-1534
- https://doi.org/10.1039/a608161d
Abstract
The Pudovik reaction of aromatic aldehydes with diethyl phosphite catalysed by either tartrate-modified titanium(IV) alkoxides or binaphthol-modified lanthanoid alkoxides has been examined. The enantioselectivity for the Pudovik reaction catalysed by tartrate-modified titanium(IV) alkoxide 1 was strongly dependent upon the solvent used. The electronic nature of the carbonyl affected the enantioselectivity for the Pudovik reaction with the La-Li-BINOL complex 2.Keywords
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