Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants
- 24 November 1995
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 270 (5240) , 1360-1362
- https://doi.org/10.1126/science.270.5240.1360
Abstract
Immune evasion by the human immunodeficiency virus (HIV) is unexplained but may involve the mutation of viral antigens. When cytotoxic T lymphocytes engaged CD4-positive cells that were acutely infected with HIV bearing natural variant epitopes in reverse transcriptase, substantial inhibition of specific antiviral lysis was observed. Mutant viruses capable of these transactive effects could facilitate the persistence of a broad range of HIV variants in the face of an active and specific immune response.Keywords
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