Some effects of propionate upon acetate metabolism in animal tissue slices

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Abstract
Propionate, in equimolar concentration, largely abolished the production of Cl4O2 from carboxyl-labeled acetate by rat-liver slices. Butyrate, isovalerate, valine, isoleucine and methionine inhibited acetate oxidation to varying degrees. The oxidation of propionate was not decreased by acetate. Acetate oxidation by slices of other rat tissues was inhibited by propionate, but to a lesser degree than with rat-liver slices. The uptake of acetate and the incorporation of its carboxyl-C into ketone bodies by rat-liver slices were also strongly inhibited by propionate. The oxidation of carboxyl-labeled butyrate by rat liver was not inhibited by propionate; the oxidation of C(2) -labeled pyruvate was affected to a much smaller extent than that of acetate. The effects of propionate on acetate metabolism by sheep-liver slices were much smaller than those observed with rat liver. The endogenous ketone-body production of sheep liver was less than that of rat liver.