Amplification of the c-erbB oncogene is associated with malignancy in primary tumours of neuroepithelial tissue
- 1 July 1991
- journal article
- Published by Springer Nature in Zeitschrift für Neurologie
- Vol. 238 (4) , 221-224
- https://doi.org/10.1007/bf00314785
Abstract
In various primary brain tumours of neuroepithelial tissue recombinant DNA techniques were used to demonstrate changes of the epidermal growth factor receptor gene, which is homologous to the c-erbB oncogene. Twenty-one of 40 grade III/IV tumours, but only 1 of 16 grade I/II tumours were found to contain amplified and/or rearranged c-erbB sequences. This highly significant difference suggest that c-erbB amplification, rearrangement, or both, are important steps in malignant transformation in a subset of patients with neuroepithelial tumours.Keywords
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