Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1
- 8 August 2005
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 335 (3) , 836-842
- https://doi.org/10.1016/j.bbrc.2005.07.152
Abstract
No abstract availableKeywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology
This publication has 19 references indexed in Scilit:
- Phosphorylation and Functional Inactivation of TSC2 by Erk: Implications for Tuberous Sclerosisand Cancer PathogenesisPublished by Elsevier ,2005
- Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityNature, 2004
- The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteinsThe Journal of cell biology, 2004
- Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylationBiochemical and Biophysical Research Communications, 2004
- Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 PhosphorylationJournal of Biological Chemistry, 2003
- A central role for JNK in obesity and insulin resistanceNature, 2002
- Mechanism of action of the immunosuppressant rapamycinPublished by Elsevier ,1999
- Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 AdipocytesPublished by Elsevier ,1996
- IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin ResistanceScience, 1996
- Insulin-stimulated GLUT4 Translocation Is Mediated by a Divergent Intracellular Signaling PathwayPublished by Elsevier ,1995