Comparative analysis of module-based versus direct methods for reverse-engineering transcriptional regulatory networks
Open Access
- 7 May 2009
- journal article
- research article
- Published by Springer Nature in BMC Systems Biology
- Vol. 3 (1) , 49
- https://doi.org/10.1186/1752-0509-3-49
Abstract
A myriad of methods to reverse-engineer transcriptional regulatory networks have been developed in recent years. Direct methods directly reconstruct a network of pairwise regulatory interactions while module-based methods predict a set of regulators for modules of coexpressed genes treated as a single unit. To date, there has been no systematic comparison of the relative strengths and weaknesses of both types of methods.Keywords
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