Assessment of [11C]-L-Methionine Transport into the Human Brain
Open Access
- 1 June 1988
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 8 (3) , 341-345
- https://doi.org/10.1038/jcbfm.1988.69
Abstract
Neutral amino acid transport into human brain was measured using a dual-probe positron detection system or positron emission tomography (PET). Rate constants (ml/min/cc) for brain accumulation of [11C]L-methionine measured with the dual detector ranged from 0.012 to 0.078 (average 0.031) under baseline conditions and from 0.010 to 0.017 (average 0.014) after administration of nonradioactive L-phenylalanine (100 mg/kg). The net rate of brain accumulation of L-methionine ranged from 0.42 to 2.89 (average 1.28) nmol/min/cc, and decreased by 27.5–91.2% (average 53.9%) after L-phenylalanine. PET-estimated accumulation rates (ml/min/cc) of [11C]L-methionine ranged from 0.004 to 0.028 (average 0.016) baseline and from 0.010 to 0.021 (average 0.017) after L-phenylalanine. Initial volumes of distribution (ml/cc) of [11C]L-methionine (dual detector) were 0.044–0.070 (average 0.058) baseline and 0.032–0.074 (average 0.051) after phenylalanine and (PET) 0.026–0.098 (average 0.051) baseline and 0.021–0.061 (average 0.042) after phenylalanine. PET permits more accurate measurement of tracer accumulation by brain, excluding noncerebral regions included in dual-detector measurements. The dual-detector system permits better temporal resolution, facilitating kinetic analysis, and requires only one-fortieth the dose of tracer needed for PET. Multiple studies in the same patient are thus possible at low cost.This publication has 19 references indexed in Scilit:
- PET Study of Methionine Accumulation in Glioma and Normal Brain TissueJournal of Computer Assisted Tomography, 1987
- Inhibition of L‐{18F}fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomographyAnnals of Neurology, 1986
- Kinetic Constants for Blood—Brain Barrier Amino Acid Transport in Conscious RatsJournal of Neurochemistry, 1985
- Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake DataJournal of Cerebral Blood Flow & Metabolism, 1983
- Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: A re-examinationBrain Research Reviews, 1982
- KINETICS OF COMPETITIVE INHIBITION OF NEUTRAL AMINO ACID TRANSPORT ACROSS THE BLOOD‐BRAIN BARRIERJournal of Neurochemistry, 1977
- Aromatic Amino Acid Supply and Brain Protein SynthesisPublished by Wiley ,1974
- The influx of amino acids into the brain of the rat in vivo : the essential compared with some non-essential amino acidsProceedings of the Royal Society of London. B. Biological Sciences, 1973
- Free Tryptophan in Plasma and Brain Tryptophan MetabolismNature, 1972
- Facilitated transport of amino acids through the blood-brain barrier of the dog studied in a single capillary circulationBrain Research, 1972