Effect of Vasoactive Intestinal Polypeptide (VIP) on the Lower Esophageal Sphincter Pressure (LESP)

1 May 1977

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 155 (1) , 40-43
https://doi.org/10.3181/00379727-155-39740

Abstract

The effect of vasoactive intestinal polypeptide (VIP) on the lower esophageal sphincter (LES) was studied in anesthetized opossums. I.v. administration of VIP caused a dose-related fall in LES pressure. A dose of 8 .mu.g/kg produced a maximal fall of 36.8 .+-. 2.9 mm Hg (80.5 .+-. 4.5%) in sphincter pressure. The effect of VIP (8 .mu.g/kg) was not antagonized by tetrodotoxin in the doses which antagonized neural activity in the LES. .beta.-Adrenergic antagonist, propranolol, also failed to antagonize this inhibitory effect of VIP. VIP exerts an inhibitory effect on the LES. Moreover, this inhibitory effect may be due to a direct action on the sphincter muscle.

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