Sequential medical trials
- 1 June 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (6) , 3135-3138
- https://doi.org/10.1073/pnas.77.6.3135
Abstract
A model for sequential clinical trials to select the better of 2 treatments is discussed. Three proposed stopping rules are studied by the Monte Carlo method for small patient horizons and mathematically for large patient horizons. They are about equally effective and asymptotically optimal from both Bayesian and frequentist points of view and are markedly superior to any fixed sample size procedure.Keywords
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