Immunopathologic Aspects of Infection with Lagos Bat Virus of the Rabies Serogroup

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Abstract
After intracerebral inoculation of Lagos bat virus, immunosuppression by either Cytoxan or thymectomy and sublethal irradiation prolonged survival and decreased the incidence of paralytic signs in random-bred Charles River mice. A similar effect after Cytoxan treatment was observed in BALB/c mice, but not in C57BL/6, or A strain mice. Weanling hamsters treated with Cytoxan showed only a decrease in the incidence of paralytic signs. The administration of Lagos bat virus antibody to immunosuppressed Charles River mice on day 8 after inoculation of a high dose of virus was followed by rapid paralysis and early death. Preliminary attempts to apply this model to rabies virus indicate that biologic differences among strains of rabies may be an important determinant for detection of the measurable effect of immunosuppression.

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