Is “Transient Tachypnoea of the Newborn” Always a Benign Disease? Report of 6 Babies Requiring Mechanical Ventilation

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Abstract
Tudehope, D. I., and Symth, Margaret H. (1979). Aust. Paediatr. J., 15, 160–165. Is “transient tachypnoea of the newborn” always a benign disease? Report of 6 babies requiring mechanical ventilation. A retrospective study in an intensive care nursery revealed that transient tachypnoea of the newborn (TTN) was the commonest cause of respiratory distress. This condition was frequently associated with marginal prematurity, hypoproteinaemia, birth asphyxia, Caesarean section, breech presentation and male babies. The signs associated with TTN abated by 48 hours in 74% of the babies; the remainder had a prolonged, often complicated course. Six of the nine babies with signs persisting more than 46 hours required mechanical ventilation; three because of hypoxaemia and three with severe respiratory acidosis. Babies with the clinical signs and radiographic features consistent with TTN may develop severe ventilation‐perfusion imbalance, fatigue and pulmonary hypertension with right to left shunting of blood across the ductus arteriosus.

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