Hormonal Regulation of Ovarian Folliculogenesis in Rhesus Monkeys: III. Atresia of the Preovulatory Follicle Induced by Exogenous Steroids and Subsequent Follicular Development12

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Abstract
This experiment was designed to determine the effect of exogenous steroids on the preovulatory follicle and to evaluate subsequent ovarian and pituitary function as related to development of a substitute follicle. The original preovulatory follicle was identified by laparoscopy on Day 6 of the menstrual cycle in 29 monkeys, and Silastic capsules containing cholesterol, estradiol-17β (E2), or progesterone (P) were implanted s.c. in the following groups of animals: A) one cholesterol capsule for 48 h, B) six E2 capsules for 48 h, C) four E2 capsules for 48 h, D) four E2 capsules for 24 h, E) four E2 plus one P capsule for 48 h, and F) one P capsule for 48 h. Serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), E2, and P were determined by radioimmunoassay.