Biologic Changes in Sulfonamide-resistant Mycobacterium ranae

Publisher Website
Google Scholar
Abstract
A sulfonamide-resistant strain of M. ranae which gave luxuriant growth in the. presence of 200 mg. % sulfathiazole was produced from a strain sensitive to 1 mg. % after 23 transfers during a period of 3 mos. The resistant strain differed from the parent strain in the following respects: It maintained high resistance over a period of 10 mos.; it was resistant to all sulfonamide agents tested; it had a much slower growth, rate; it produced a discoloration in the media; it was more susceptible to antibacterial agents (probably due to slower growth rate); and it was more susceptible to bac-teriostasis by PABA. The implications concerning the mechanism of sulfonamide activity are discussed.