The Relative Biological Effectiveness in V79 Chinese Hamster Cells of the Neutron Capture Reactions in Boron and Nitrogen

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Abstract
V79 [lung fibroblast] Chinese hamster cells were irradiated in the presence of different amounts of boric acid with thermal neutrons. From the linear dose-survival curves observed, a D0 [mean lethal dose] value of 66 rad for the 10B(n,.alpha.)7Li neutron capture reaction was obtained. No dependence of this value on the concentration of boric acid was found. Comparing the value to the D0 value of 150 rad obtained with 250 kVp [kilovolt peak] X rays between 10 and 0.01% survival, an extrapolated RBE [relative biological control] value of 2.3 was calculated. By irradiation of the same line of cells with cold neutrons, a D0 value for the 14N(n,p)14C reaction of 77 rad was obtained, with a corresponding RBE value of 1l9. Comparison is made with previously published RBE values for the 10B(n,.alpha.)7Li reaction.

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