Comparison of Buffered and Unbuffered Acetylsalicylic Acid

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Abstract
FEW drugs have such a wide clinical use and acceptance as acetylsalicylic acid. Gerhardt1 synthesized this substance in 1853, but it remained for Hoffman, a chemist at Bayer's chemical works at Elberfeld, Germany, to rediscover the compound. The inadequacy of prolonged use of salicylic acid for the treatment of his father's rheumatoid arthritis prompted Hoffman to try acetylsalicylic acid. Because of its success he influenced Dreser, the director of Bayer's pharmacologic research, to initiate pharmacologic and clinical studies. In 1899 Dreser2 presented the first pharmacologic data, and Wohlgemut3 the first clinical report. Thus began a literature that is now too . . .

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