Effect of Selenium on Appetite in the Selenium-Deficient Chick

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Abstract
Experiments were conducted to determine the initial effects of oral selenium administration on selenium-deficient chicks. Administration of 5 µg selenium as seleno-DL-methionine increased voluntary feed consumption within 2–3 hours, whereas selenite did not have a significant effect until 3–4 hours. Spontaneous activity, body weight gain and plasma glucose concentration increased 6–8 hours after selenium administration. The earliest response in the specific activity of selenium-dependent glutathione peroxidase occurred in plasma at 8 hours and in liver at 24 hours after selenium administration. The onset of pancreatic atrophy, however, was not affected by the level of feed intake suggesting that the effect of selenium upon appetite may be distinct from the involvement of selenium in nutritional pancreatic atrophy and fibrosis.