Iron and Deferoxamine in Lymphocyte Blastogenesis
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Journal of Immunopharmacology
- Vol. 2 (2) , 179-187
- https://doi.org/10.3109/08923978009026396
Abstract
Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of Fe is related to the time of maximal activity of DNA synthesis. A chelator of Fe, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 .mu.M. Fe is necessary for the blastogenic response, and may partially explain the immune deficiency associated with Fe deficiency anemia.This publication has 9 references indexed in Scilit:
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