Maintenance of Noradrenaline Synthesis in Rats after Reserpine Treatment

Publisher Website
Google Scholar
Abstract
Studies of the excretion in the urine of noradrenaline (NA) and 3‐methoxy‐4‐hydroxymandelic acid (VMA) during 5 days treatment with 0.05—0.1 rpg/kg of reserpine in rats with demedullated adrenal glands arc reported. The excretion of NA was moderately reduced but VMA excretion was not significantly influenced by this treatment, although the heart was almost completely depleted of NA within 48 hours. These results indicate that synthesis of NA may continue in spite of reserpine treatment causing tissue depletion of the amine, suggesting the normal storage is not a prerequisite for resynthesis.