The Determination of 4,4′-Methylenebis(2-Chloroaniline) in Urine by Electron Capture Gas Chromatography

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Abstract
The development and use of a gas chromatographic method for monitoring workers who are occupationally exposed to 4,4′-methylenebis(2-chloroaniline) (MBOCA) is reported. The increase in ether-extractable MBOCA on mild hydrolysis is reported and the optimum conditions for hydrolysis determined. The analytical conditions for a specific and sensitive electron capture gas chromatographic method that will measure both “free” MBOCA and “total” MBOCA are established. It is suggested that workers should be monitored by the measurement of “total” urinary MBOCA.