The effect of temperature on tolerance to ischemia in experimental free flaps

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Abstract
Extended groin flaps in rats were used to explore the relationship of time and temperature of ischemic storage to the ultimate survival of free flaps. The maximum period of ischemia with 100% survival was found to be six hours for storage at a normothermic range (20‐ 25‐ C) and 48 hours for storage at a hypothermic range (0‐ 5 C). This study confirms the findings of others that cooling of tissue increases the interval of ischemic storage in which composite tissue can withstand and still survive.