Scyllo-inositol in normal aging human brain:1H magnetic resonance spectroscopy study at 4 Tesla

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Abstract
The scyllo‐inositol and myo‐inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single‐voxel short‐echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test–retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo‐inositol measurement of 37%, compared with 6% for N‐acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo‐inositol and myo‐inositol in older subjects and a trend for a correlation between scyllo‐inositol and myo‐inositol levels across subjects. Copyright © 2004 John Wiley & Sons, Ltd.