Actinomycin D: Inhibition of Respiration and Glycolysis
- 24 February 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 151 (3713) , 1007-1010
- https://doi.org/10.1126/science.151.3713.1007
Abstract
Actinomycin D inhibited respiration and anaerobic glycolysis of human leukemic leukocytes and lowered the adenosine triphosphate content of the cells. Inhibitory effects on respiration and on RNA synthesis could not be dissociated from one another over a wide range of drug concentrations. Actinomycin D also impaired protein synthesis, probably by decreasing the availability of adenosine triphosphate and by inhibiting messenger RNA.Keywords
This publication has 4 references indexed in Scilit:
- Actinomycin D: Inhibition of Protein Synthesis Unrelated to Effect on Template RNA SynthesisScience, 1965
- A novel effect of actinomycin D in preventing bacteriophage T4 maturation in Escherichia, coliBiochemical and Biophysical Research Communications, 1965
- Actinomycin D: An Effect on Rat Liver Homogenates Unrelated to Its Action on RNA SynthesisScience, 1964
- Crystalline firefly luciferaseBiochimica et Biophysica Acta, 1956