Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease
- 1 March 1992
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 4 (1) , 27-34
- https://doi.org/10.1007/bf02257619
Abstract
Mitochondrial Complex I deficiencies have been described not only in the brain but also in the skeletal muscle and platelets in Parkinson's disease (PD). We report activities of Complex I, II, III, and IV in lymphocytes and platelets in 20 patients with PD and age-matched controls. A small but a significant decrease in the platelet Complex I activity was found in PD (9.14±1.86 units/mg protein) compared with that in the control (12.37±2.66 units/mg protein) (P=0.0002). The lymphocyte Complex I activity was about the same between PD and the control. The activity of Complex II was slightly diminished in both platelets and lymphocytes in PD. Rather small decrease in the platelet Complex I activity in PD may be clinically non-significant. But it may indicate the presence of a qualitatively similar abnormality in platelets as in the nigro-striatal neurons. The cause for decrease in the Complex II activity is unknown at this moment. Further studies seem necessary.Keywords
This publication has 27 references indexed in Scilit:
- Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridinePublished by Elsevier ,2002
- Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescenceBiochemical and Biophysical Research Communications, 1990
- Deficiencies in Complex I subunits of the respiratory chain in Parkinson's diseaseBiochemical and Biophysical Research Communications, 1989
- Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinolineBiochemical and Biophysical Research Communications, 1989
- An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regionsNeuroscience Letters, 1988
- Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in Parkinsonian and normal human brainsBiochemical and Biophysical Research Communications, 1987
- Inhibition of mitochondrial alpha-ketoglutarate dehydrogenase by 1-methyl-4-phenylpyridinium ionBiochemical and Biophysical Research Communications, 1987
- Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenylpyridinium ionBiochemical and Biophysical Research Communications, 1987
- Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonismBiochemical and Biophysical Research Communications, 1986
- Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+Biochemical and Biophysical Research Communications, 1986