A STUDY OF THE ROLES OF ADRENOCORTICAL STEROIDS AND GLOMERULAR FILTRATION RATE IN THE MECHANISM OF THE DIURNAL RHYTHM OF WATER AND ELECTROLYTE EXCRETION

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Abstract
SUMMARY: 1. An investigation of the mechanism of diurnal excretory rhythms has been carried out on four healthy male subjects in whom the excretory rhythms were reversed by a 12 hr. shift of the activity—sleep and light—dark schedules. 2. The diurnal rhythms of water, sodium, potassium, creatinine and ketogenic steroid excretion adapted to the reversal of routine at different rates. 3. It is concluded, from the dissociation of these rhythms during the reversal phase, that the ketogenic steroids are not controlling either the major variation of glomerular filtration rate or the excretory rhythms of water and sodium. 4. The potassium excretory rhythm appears to be linked with the ketogenic steroid rhythm. 5. The mechanism of the diurnal rhythm of urine flow is discussed in relation to these findings.

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