Effect of Long-Term Administration of Epinephrine and Propranolol on Serum Calcium, Parathyroid Hormone, and Calcitonin in the Rat

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Abstract
Injection of epinephrine to 250-300 g rats (0.3 mg/day for 2 wk, followed by 0.6 mg/day for another 3 wk) progressively increased the serum PTH [parathyroid hormone] and CT [calcitonin], whereas administration of approximately 40 mg of propranolol daily, in drinking water, progressively decreased the serum levels of both these hormones in comparison to control animals. Similar to the short-term effects observed in previous studies, long-term modification of .beta.-adrenergic stimuli can apparently affect PTH and CT secretions.