A COMPARISON OF ORAL ADMINISTRATION VERSUS INTRAPERITONEAL INJECTION OF COLLOIDAL IRON UPON BLOOD REGENERATION IN NUTRITIONAL ANEMIA OF THE RAT

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Abstract
Young weanling rats were made anemic by feeding on cow''s milk containing an average of 0.11 mg. Cu per liter. The total amount of colloidal Cu-free Fe required for complete blood regeneration was then compared and the per cent utilization of Fe on Hb formation determined. 2 mg. colloidal Fe injected weekly for 4 weeks (8 mg.) was as effective on blood regeneration as 2 mg. ingested daily by mouth for 3 weeks (42 mg.) 0.26 mg. injected every other day for 3 weeks (2.73 mg.) was as effective as the ingestion of 0.26 mg. daily by mouth for 5.5 weeks (10 mg.). The utilization of colloidal Fe by mouth on Hb formation was 1/4 as great as that of the injected. 0.13 mg. of injected colloidal Fe daily is the minimum dose required for Hb regeneration.

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