Application of orthogonal functions to the spectrophotometric determination of phenytoin and phenobarbitone in pharmaceutical preparations
- 1 September 1977
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1) , 355-357
- https://doi.org/10.1111/j.2042-7158.1977.tb11334.x
Abstract
Orthogonal polynomial functions have been used in the simultaneous determination of mixtures of phenytoin and phenobarbitone in pharmaceutical preparations. The mean recovery (9 determinations) and coefficient of variation were 100·0 ± 1·4% for phenobarbitone and 100·0 ± 1·3% for phenytoin. Neither the ΔA method of Pannerden & Fontein nor a ΔA modification of Vierordt's method of two-component analysis gave results of the same accuracy and precision as the proposed method.Keywords
This publication has 3 references indexed in Scilit:
- Comments on the Determination of Diphenylhydantoin (cont.)Clinical Chemistry, 1974
- Application of the ΔA method to the determination of morphineJournal of Pharmacy and Pharmacology, 1970
- Conditions for securing accuracy in spectrophotometryProceedings of the Physical Society, 1933