Immunomodulating Activity of 3-(P-Chlorophenyl)Thiazolo-[3,2-A]Benzimidazole-Z-Acetic Acid (Wy-18,251, Nsc 310633) in Mice Implanted with Lewis Lung Tumor. Effect of Wy-18,251 on Lymphocyte Proliferation and Phagocytosis
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Journal of Immunopharmacology
- Vol. 5 (4) , 333-340
- https://doi.org/10.3109/08923978309026452
Abstract
Proliferation of B lymphocytes is depressed in Lewis lung tumor bearing mice. Treatment of these mice with Wy-18,251 (5 mg/kg) significantly increased the responsiveness of their splenic T cells to concanavalin A in cell culture. Levamisole (5 mg/kg) acted more weakly than Wy-18,251. Neither Wy-18,251 nor levamisole elevated the depressed B cell mitogenesis. Wy-18,251 significantly increased macrophage phagocytosis against 51chromium labeled opsonized chicken red blood cells. Levamisole behaved differently: it either had no effect on phagocytosis, or depressed it.This publication has 6 references indexed in Scilit:
- Immunomodulating and Antimetastatic Activity of 3–(P-Chlorophenyl) Thiazolo[3, 2-A]Benzimidazole-2-Acetic Acid (Wy-18, 251, Nsc 310633)Journal of Immunopharmacology, 1980
- The immunostimulatory activity of 3-(p-chlorophenyl)-2,3-dihydro-3-hydroxythiazole [3, 2-α]-benzimidazole-2-acetic acid (NSC 208828)Published by Elsevier ,1978
- Effect of Immunomodulators on Effector Cells Involved in Antibody-Dependent Cellular Cytotoxicity: Brief Communication2JNCI Journal of the National Cancer Institute, 1977
- Anti-tumour and anti-metastatic activity of 3-(P-Chlorophenyl)-2,3-Dihydro-3-Hydroxythiazolo [3,2-a]-Benzimidazole-2-acetic acid (WY-13,876)British Journal of Cancer, 1976