Association of serum lipoprotein(a) concentration with other cardiovascular risk factors in a chinese population

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Abstract
The association between serum Lp(a) concentration, a risk factor for atherothrombotic disease, and other cardiovascular risk factors such as smoking, alcohol intake, hypertension, obesity, and indices of glycemic control is examined in a cohort of 313 elderly Chinese subjects (M = 160, mean age ± SD = 68 ± 11 year; F = 153, mean age ± SD = 73 ± 11). Although associations existed for the above risk factors and other serum lipid levels, there was no association with serum Lp(a) concentration in the overall population. Men with Lp(a) ≥ 30 mg/dl had a higher mean age and blood pressure. A higher percentage of subjects with Lp(a) ≥ 30 mg/dl had a family history of stroke, although the total number of those with a family history was too small to reach statistical significance. The lack of association with known modifiable cardiovascular risk factors is compatible with the conclusion that Lp(a) concentration is primarily under genetic control and therefore unlikely to be a modifiable risk factor.