Toxicity of Endotoxin to Chicks

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Abstract
Large doses of purified lipopolysaccharide (LPS) purified from Escherichia coli induced clinical signs but no mortality in chicks. Five chicks survived a mean dose of 517 mg/kg. One individual that received LPS at 577 mg/kg recovered from clinical manifestations within 2 days. Attempts failed to produce a generalized Shwartzman-like reaction with 2 i.v. inoculations of LPS at about 24-h intervals. Prior injection of uric acid did not protect chicks from LPS by i.v. exposure.

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